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GSK2606414
CAS No. 1337531-36-8
GSK2606414( GSK2606414 | GSK-2606414 | GSK PERK Inhibitor )
Catalog No. M11350 CAS No. 1337531-36-8
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 55 | In Stock |
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| 5MG | 86 | In Stock |
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| 10MG | 116 | In Stock |
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| 50MG | 314 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGSK2606414
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NoteResearch use only, not for human use.
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Brief DescriptionGSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
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DescriptionGSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.(In Vitro):GSK2606414 inhibits PERK activation in cells.(In Vivo):GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
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In VitroGSK2606414 inhibits PERK activation in cells.
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In VivoGSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
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SynonymsGSK2606414 | GSK-2606414 | GSK PERK Inhibitor
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PathwayApoptosis
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TargetPERK
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RecptoreIF-2AK1 (HRI)| eIF-2AK2 (PKR)| eIF-2AK3 (PERK)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1337531-36-8
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Formula Weight451.44
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Molecular FormulaC24H20F3N5O
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Purity>98% (HPLC)
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SolubilityEthanol: 19 mg/mL (42.08 mM); DMSO: 90 mg/mL (199.36 mM)
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SMILESFC(C1=CC(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3)=O)=CC=C1)(F)F
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Chemical Name1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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