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PD146176

CAS No. 4079-26-9

PD146176( NSC168807 )

Catalog No. M24370 CAS No. 4079-26-9

PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PD146176
  • Note
    Research use only, not for human use.
  • Brief Description
    PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
  • Description
    PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Triple transgenic (3xTg) mice Dosage:80 mg/kg Administration:Chowing; 12 weeks Result:Significantly lower amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autophagy activation.
  • Synonyms
    NSC168807
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    15-LO|Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4079-26-9
  • Formula Weight
    237.32
  • Molecular Formula
    C15H11NS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:25 mg/mL (105.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
  • SMILES
    C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201]. Atherosclerosis. 1998;136(2):203-216.
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