PD146176

CAS No. 4079-26-9

PD146176( NSC168807 )

Catalog No. M24370 CAS No. 4079-26-9

PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 In Stock
10MG 67 In Stock
25MG 133 In Stock
50MG 248 In Stock
100MG 434 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PD146176
  • Note
    Research use only, not for human use.
  • Brief Description
    PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
  • Description
    PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Triple transgenic (3xTg) mice Dosage:80 mg/kg Administration:Chowing; 12 weeks Result:Significantly lower amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autophagy activation.
  • Synonyms
    NSC168807
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    15-LO|Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4079-26-9
  • Formula Weight
    237.32
  • Molecular Formula
    C15H11NS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:25 mg/mL (105.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
  • SMILES
    C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201]. Atherosclerosis. 1998;136(2):203-216.
molnova catalog
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