PC1244

Research use only, not for human use.

PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B.

PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM; demonstrates potent antifungal activities against clinical A. fumigatus isolates with a MIC range of 0.016-0.25 ug/mL; PC1244 is also effective against a broad spectrum of pathogenic fungi (MIC= <0.0078-2 μg/ml), especially on Aspergillus terreus, Trichophyton rubrum, Candida albicans; shows fungicidal activity (MFC=2 μg/ml), 8-fold more potent than voriconazole; shows superior in vivo effects in immunocompromised mice.

PC 1244

Microbiology/Virology

Fungal

Fungal

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2046185-88-8

686.81

C38H44F2N6O4

>98% (HPLC)

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4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-N-((1S,2S)-2-hydroxycyclohexyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years