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PBT-1033

CAS No. 747408-78-2

PBT-1033( PB 1033 | PBT-2 | PBT1033 | PBT2 | PBT 1033 | PBT 2 )

Catalog No. M24759 CAS No. 747408-78-2

PBT-1033(PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 237 In Stock
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Biological Information

  • Product Name
    PBT-1033
  • Note
    Research use only, not for human use.
  • Brief Description
    PBT-1033(PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
  • Description
    PBT-1033(PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
  • In Vitro
    PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5?μM.PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity.PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons.PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells.PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates. Western Blot Analysis Cell Line:SH-SY5Y cells Concentration:0-10 μM Incubation Time:1 h Result:Increased in cellular levels of GSK3α/β phosphorylated at the inhibitory serine 21/9 residue (ser21/9 on GSK3α/β).
  • In Vivo
    PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease. Animal Model:Female Tg2576 miceDosage:30 mg/kg/d Administration:Oral administration, 11 days Result:Increased hippocampal apical spine density, basal spine density.
  • Synonyms
    PB 1033 | PBT-2 | PBT1033 | PBT2 | PBT 1033 | PBT 2
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    747408-78-2
  • Formula Weight
    271.14
  • Molecular Formula
    C12H12Cl2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (368.81 mM)
  • SMILES
    CN(C)Cc1ccc(c(Cl)cc(Cl)c2O)c2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Huntington Study Group Reach2HD Investigators.. Safety, tolerability, and efficacy of PBT2 in Huntington's disease: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Jan;14(1):39-47. doi: 10.1016/S1474-4422(14)70262-5. PubMed PMID: 25467848.
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