PARP-1-IN-4

CAS No. 684234-56-8

PARP-1-IN-4( —— )

Catalog No. M37149 CAS No. 684234-56-8

PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 Get Quote
10MG 61 Get Quote
25MG 118 Get Quote
50MG 196 Get Quote
100MG 286 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    PARP-1-IN-4
  • Note
    Research use only, not for human use.
  • Brief Description
    PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
  • Description
    PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma.
  • In Vitro
    Cell Proliferation Assay Cell Line:A549 cells Concentration:0.1, 1 and 10 μM Incubation Time:24h and 48h Result:Exhibited cytotoxicity activity against A549 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    684234-56-8
  • Formula Weight
    424.28
  • Molecular Formula
    C22H15Cl2N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 7.69 mg/mL (18.12 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C )
  • SMILES
    O=C(NC1=CC=C(Cl)C=C1)CN2N=C(C=3C=CC(Cl)=CC3)C=4C=CC=CC4C2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018;77:443-456. ?
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