Cart
sales@molnova.com
PARP-1-IN-4
CAS No. 684234-56-8
PARP-1-IN-4( —— )
Catalog No. M37149 CAS No. 684234-56-8
PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | Get Quote |
|
| 10MG | 61 | Get Quote |
|
| 25MG | 118 | Get Quote |
|
| 50MG | 196 | Get Quote |
|
| 100MG | 286 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePARP-1-IN-4
-
NoteResearch use only, not for human use.
-
Brief DescriptionPARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
-
DescriptionPARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma.
-
In VitroCell Proliferation Assay Cell Line:A549 cells Concentration:0.1, 1 and 10 μM Incubation Time:24h and 48h Result:Exhibited cytotoxicity activity against A549 cells.
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetPARP
-
RecptorPARP
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number684234-56-8
-
Formula Weight424.28
-
Molecular FormulaC22H15Cl2N3O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 7.69 mg/mL (18.12 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C )
-
SMILESO=C(NC1=CC=C(Cl)C=C1)CN2N=C(C=3C=CC(Cl)=CC3)C=4C=CC=CC4C2=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018;77:443-456. ?
molnova catalog
related products
-
Rucaparib Camsylate
Rucaparib Camsylate is a PARP inhibitor (PARP1,Ki of 1.4 nM). Rucaparib Camsylate also displays binding affinity to eight other PARP domains. Rucaparib is the most effective PARP inhibitor in enzyme assays (Ki: 1.4 nM). Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilized D283Med cells.
-
PARP-1-IN-4
PARP-1-IN-4 is a potent PARP-1 inhibitor with potential anti-tumor activity, where inhibition of PARP-1 may be applied in cancer treatment.
-
UNBS-5162
UNBS-5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.
