
PARP-1-IN-3
CAS No. 2976342-33-1
PARP-1-IN-3( —— )
Catalog No. M37144 CAS No. 2976342-33-1
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 59 | Get Quote |
![]() ![]() |
5MG | 85 | Get Quote |
![]() ![]() |
10MG | 140 | Get Quote |
![]() ![]() |
25MG | 228 | Get Quote |
![]() ![]() |
50MG | 339 | Get Quote |
![]() ![]() |
100MG | 489 | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NamePARP-1-IN-3
-
NoteResearch use only, not for human use.
-
Brief DescriptionPARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.
-
DescriptionPARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer.
-
In VitroApoptosis Analysis Cell Line:HCT116 cells Concentration:0.3, 1.5, 7.5 μM Incubation Time:48 and 72 h Result:Increased the percentage of total apoptotic cells from 1.05% (control group) to 79.49% (7.5 μM).Cell Cycle Analysis Cell Line:HCT116 cells Concentration:0.3, 1.5, 7.5 μM Incubation Time:48 and 72 h Result:Blocked the cell cycle progression at G2/M phase.Western Blot Analysis Cell Line:HCT116 cells Concentration:0.3, 1, 3 μM Incubation Time:48 h Result:Increased expression levels of γH2AX in a concentration-dependent manner.Western Blot Analysis Cell Line:HCT116 cells Concentration:0.3, 1, 3 μM Incubation Time:48 h Result:Increased the expression levels of Bax, cleaved Caspase-3 and cleaved-PARP, and decreased the expression level of Bcl-2.
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetPARP
-
RecptorPARP | Apoptosis
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2976342-33-1
-
Formula Weight425.28
-
Molecular FormulaC21H17BrN2O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (293.92 mM; Ultrasonic )
-
SMILESO=C(N)C=1C=CC=CC1OCC=2C=CC=C(C2)NC(=O)C3=CC=C(Br)C=C3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lu G, et, al. Discovery of novel benzamide derivatives bearing benzamidophenyl and phenylacetamidophenyl scaffolds as potential antitumor agents via targeting PARP-1. Eur J Med Chem. 2023 May 5;251:115243.?
molnova catalog



related products
-
OUL35
OUL35 is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.
-
PARP-2-IN-3
PARP-2-IN-3 is used as a potent PARP-2 inhibitor (IC50=0.07 μM) with anti-tumor activity that induces apoptosis and necrosis in cancer cells, and can be used for the study of breast cancer.CAS ??128-52-56-8
-
RBN-2397
RBN-2397 (0.0001-100 μM; 24 hours) inhibits cells proliferation with an IC50 value of 20 nM in NCI-H1373 lung cancer cells.