PARP-1-IN-3

CAS No. 2976342-33-1

PARP-1-IN-3( —— )

Catalog No. M37144 CAS No. 2976342-33-1

PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 59 Get Quote
5MG 85 Get Quote
10MG 140 Get Quote
25MG 228 Get Quote
50MG 339 Get Quote
100MG 489 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    PARP-1-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.
  • Description
    PARP-1-IN-3, a benzamide derivative, is a potent PARP-1 inhibitor with IC50 values of 0.25 nM and 2.34 nM for PARP-1 and PARP-2, respectively. PARP-1-IN-3 induces apoptosis and arrest cell cycle at G2/M phase. PARP-1-IN-3 can be used in research of cancer.
  • In Vitro
    Apoptosis Analysis Cell Line:HCT116 cells Concentration:0.3, 1.5, 7.5 μM Incubation Time:48 and 72 h Result:Increased the percentage of total apoptotic cells from 1.05% (control group) to 79.49% (7.5 μM).Cell Cycle Analysis Cell Line:HCT116 cells Concentration:0.3, 1.5, 7.5 μM Incubation Time:48 and 72 h Result:Blocked the cell cycle progression at G2/M phase.Western Blot Analysis Cell Line:HCT116 cells Concentration:0.3, 1, 3 μM Incubation Time:48 h Result:Increased expression levels of γH2AX in a concentration-dependent manner.Western Blot Analysis Cell Line:HCT116 cells Concentration:0.3, 1, 3 μM Incubation Time:48 h Result:Increased the expression levels of Bax, cleaved Caspase-3 and cleaved-PARP, and decreased the expression level of Bcl-2.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    PARP | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2976342-33-1
  • Formula Weight
    425.28
  • Molecular Formula
    C21H17BrN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (293.92 mM; Ultrasonic )
  • SMILES
    O=C(N)C=1C=CC=CC1OCC=2C=CC=C(C2)NC(=O)C3=CC=C(Br)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lu G, et, al. Discovery of novel benzamide derivatives bearing benzamidophenyl and phenylacetamidophenyl scaffolds as potential antitumor agents via targeting PARP-1. Eur J Med Chem. 2023 May 5;251:115243.?
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