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P7C3-A20

CAS No. 1235481-90-9

P7C3-A20( —— )

Catalog No. M17211 CAS No. 1235481-90-9

P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 30 In Stock
5MG 47 In Stock
10MG 71 In Stock
25MG 87 In Stock
50MG 152 In Stock
100MG 235 In Stock
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Biological Information

  • Product Name
    P7C3-A20
  • Note
    Research use only, not for human use.
  • Brief Description
    P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.
  • Description
    P7C3 is a drug related to latrepirdine (dimebon), which has neuroprotective and proneurogenic effects, and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders.
  • In Vitro
    Cell Viability Assay Cell Line:PC12 cells Concentration:10?μM, 20 μM, 40?μM, 60 μM, 80?μM, 100 μM Incubation Time:8 hours Result:Alleviated oxygen-glucose deprivation (OGD)-induced cytotoxicity in PC12 cells. Apoptosis Analysis Cell Line:PC12 cells Concentration:40?μM, 60 μM, 80?μM, 100 μM Incubation Time:8 hours Result:Alleviated oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells.
  • In Vivo
    Animal Model:Sprague-Dawley rats (200-250 g) induced hypoxic-ischemic (HI) injury Dosage:5?mg/kg, 10?mg/kg Administration:Intraperitoneal injection; daily; for 7 days Result:Reduced infarct volume; reversed cell loss in the cortex and hippocampus and improved motor function without causing neurotoxicity.
  • Synonyms
    ——
  • Pathway
    Tyrosine Kinase
  • Target
    Src
  • Recptor
    Others
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1235481-90-9
  • Formula Weight
    506.2
  • Molecular Formula
    C22H19Br2FN2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL. 197.55 mM; H2O : < 0.1 mg/mL
  • SMILES
    COc1cccc(c1)NCC(Cn1c2c(cc(cc2)Br)c2c1ccc(c2)Br)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. De Jesús-Cortés H, et al. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):17010-5.
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