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Oxybenzone
CAS No. 131-57-7
Oxybenzone( Oxybenzone, Benzophenone-3, 2-hydroxy-4-methoxybenzone, Eusolex-4360 )
Catalog No. M11279 CAS No. 131-57-7
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameOxybenzone
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NoteResearch use only, not for human use.
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Brief DescriptionOxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.
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DescriptionOxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays. (In Vitro):Oxybenzone (Benzophenone 3) (25 μM; 24 hours) decreases the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively and increases the relative RXRα protein level by 49%.Oxybenzone (25-100 μM; 24 hours) induces an increase in caspase-3 levels in primary cultures of mouse neocortical cells at 7 DIV. Oxybenzone-induced apoptosis involves the activation of RXRα signaling and the impairment of RXRβ/RXRγ signaling. Oxybenzone (25 μM; 24 hours) inhibits global DNA methylation as well as reduced HDAC and HAT activities in mouse embryonic neuronal cells.
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In VitroOxybenzone (Benzophenone 3) (25 μM; 24 hours) decreases the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively and increases the relative RXRα protein level by 49%.Oxybenzone (25-100 μM; 24 hours) induces an increase in caspase-3 levels in primary cultures of mouse neocortical cells at 7 DIV. Oxybenzone-induced apoptosis involves the activation of RXRα signaling and the impairment of RXRβ/RXRγ signaling. Oxybenzone (25 μM; 24 hours) inhibits global DNA methylation as well as reduced HDAC and HAT activities in mouse embryonic neuronal cells. Western Blot Analysis Cell Line:Mouse neocortical cells at 7 DIV Concentration:25 μM Incubation Time:24 hours Result:Exposure to Oxybenzone (25 μM) for 24 h decreased the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively. Treatment with Oxybenzone (25 μM) increased the relative RXRα protein level by 49%.
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In Vivo——
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SynonymsOxybenzone, Benzophenone-3, 2-hydroxy-4-methoxybenzone, Eusolex-4360
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number131-57-7
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Formula Weight228.24
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Molecular FormulaC14H12O3
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Purity>98% (HPLC)
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SolubilityWater: 69 mg/L .
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SMILESO=C(C1=CC=C(OC)C=C1O)C2=CC=CC=C2
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Chemical Name(2-hydroxy-4-methoxyphenyl)-phenylmethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gonzalez H, et al. Br J Dermatol. 2006 Feb;154(2):337-40.
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