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Home - Products - Membrane Transporter/Ion Channel - iGluR - Org-26576

Org-26576

CAS No. 1026791-61-6

Org-26576( Org26576 | Org 26576 )

Catalog No. M10131 CAS No. 1026791-61-6

A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Org-26576
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.
  • Description
    A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516; increases neuronal cell proliferation and survival in adult rodent hippocampus; produces nootropic effects in vivo.Depression Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Org26576 | Org 26576
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Depression

Chemical Information

  • CAS Number
    1026791-61-6
  • Formula Weight
    204.22518
  • Molecular Formula
    C11H12N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1N(CCC2)[C@]2([H])COC3=NC=CC=C13
  • Chemical Name
    5H,7H-Pyrido[3,2-f]pyrrolo[2,1-c][1,4]oxazepin-5-one, 8,9,9a,10-tetrahydro-, (9aS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jordan GR, et al. Neuropharmacology. 2005 Aug;49(2):254-64. 2. Su XW, et al. Psychopharmacology (Berl). 2009 Oct;206(2):215-22. 3. Hamlyn E, et al. Behav Pharmacol. 2009 Oct;20(7):662-7. 4. Bursi R, et al. Psychopharmacology (Berl). 2011 Dec;218(4):713-24.
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    A potent AMPA receptor positive allosteric modulator; displays 10-30 fold greater potency in potentiating AMPA-mediated electrophysiological responses with an EC50 of 8-16 uM in rat hippocampal primary cultured neurons, compared to CX516.

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