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Omipalisib
CAS No. 1086062-66-9
Omipalisib ( GSK-212;GSK-2126458;GSK2126458 )
Catalog No. M10336 CAS No. 1086062-66-9
A highly potent dual inhibitor PI3K/mTOR inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 51 | In Stock |
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| 10MG | 87 | In Stock |
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| 25MG | 160 | In Stock |
|
| 50MG | 264 | In Stock |
|
| 100MG | 404 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOmipalisib
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent dual inhibitor PI3K/mTOR inhibitor.
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DescriptionA highly potent dual inhibitor PI3K/mTOR inhibitor with app Ki of 19/130/24/60/180/300 nM for p110α/p110β/p110γ/p110δ/mTORC1/mTORC2 respectively; shows equivalent activity for p110α mutants E542K/E545K/H1047R with Ki of 8/8/9 nM; inhibits pAKT-S473 in T47D cells (IC50=0.41 nM), also inhibits phosphorylation of AKTT308 and p70S6K; active in vivo and orally bioavailable.Solid Tumors Phase 1 Clinical
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SynonymsGSK-212;GSK-2126458;GSK2126458
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptormTORC1;p110α;p110β;p110γ;p110δ
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1086062-66-9
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Formula Weight505.50
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Molecular FormulaC25H17F2N5O3S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=S(C1=CC=C(F)C=C1F)(NC2=CC(C3=CC=C4N=CC=C(C5=CC=NN=C5)C4=C3)=CN=C2OC)=O
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Chemical NameBenzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Knight SD, et al. ACS Med Chem Lett. 2010 Jan 19;1(1):39-43.
2. Khalili JS, et al. Clin Cancer Res. 2012 Aug 15;18(16):4345-55.
3. Munster P, et al. Clin Cancer Res. 2016 Apr 15;22(8):1932-9.
2. Khalili JS, et al. Clin Cancer Res. 2012 Aug 15;18(16):4345-55.
3. Munster P, et al. Clin Cancer Res. 2016 Apr 15;22(8):1932-9.
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