Ombuin

Research use only, not for human use.

Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process.

Ombuin has anti-inflammatory activity, it inhibits some macrophage functions involved in the inflammatory process.(In Vitro):Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose-dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h.

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GPCR/G Protein

Antibacterial

Antibacterial

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529-40-8

330.3

C17H14O7

>98% (HPLC)

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COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(O)c2=O

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(-20℃)

With Ice Pack

≥ 2 years