Omadacycline( Amadacycline | PTK 0796 )

Catalog No. M19962 CAS No. 389139-89-3

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Product Name

Omadacycline
Note

Research use only, not for human use.
Brief Description

Omadacycline a new tetracycline antibiotic can inhibit the 30s subunit of bacterial ribosome.
Description

Omadacycline a new tetracycline antibiotic can inhibit the 30s subunit of bacterial ribosome.
In Vitro

Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively.Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux.
In Vivo

Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg.
Synonyms

Amadacycline | PTK 0796
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

ribosome 30s subunit
Research Area

Inflammation/Immunology
Indication

Cystitis; Pyelonephritis; Urinary tract infections

CAS Number

389139-89-3
Formula Weight

556.65
Molecular Formula

C29H40N4O7
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(CNCC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C
Chemical Name

——

1.Shoen C et al. In vitro activities of omadacycline against rapidly growing mycobacteria. Antimicrob Agents Chemother. 2019 Mar 11.

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