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Home - Products - GPCR/G Protein - Antibacterial - AU-1235

AU-1235

CAS No. 1338780-86-1

AU-1235( AU1235 )

Catalog No. M11362 CAS No. 1338780-86-1

AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AU-1235
  • Note
    Research use only, not for human use.
  • Brief Description
    AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor.
  • Description
    AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor with MIC of 0.1 ug/mL (0.3 uM) against Mtb H37Rv.
  • In Vitro
    AU1235 is similarly active against MDR isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum although the MICs (3.2 to 6.4 μg/ml) are significantly higher than against M. tb and M. bovis BCG.
  • In Vivo
    ——
  • Synonyms
    AU1235
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1338780-86-1
  • Formula Weight
    324.347
  • Molecular Formula
    C17H19F3N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 6 mg/mL 18.50 mM
  • SMILES
    C1C2CC3CC1CC(C2)(C3)NC(=O)NC4=C(C(=C(C=C4)F)F)F
  • Chemical Name
    N-Tricyclo[3.3.1.13,7]dec-1-yl-N'-(2,3,4-trifluorophenyl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Grzegorzewicz AE, et al. Nat Chem Biol. 2012 Feb 19;8(4):334-41. 2. Stanley SA, et al. ACS Chem Biol. 2012 Aug 17;7(8):1377-84.
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