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Olodaterol

CAS No. 868049-49-4

Olodaterol ( BI1744 CL )

Catalog No. M16305 CAS No. 868049-49-4

A potent, selective long-acting β2 adrenoceptor agonist with EC50 of 1.4 nM for hβ2; shows >250 fold selectivity over hβ1; exerts a bronchodilatory efficacy over 24 h in dogs and guinea pigs in the absence of systemic pharmacodynamic effects.COPDPhase 3 Clinical

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Olodaterol
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective long-acting β2 adrenoceptor agonist with EC50 of 1.4 nM for hβ2; shows >250 fold selectivity over hβ1; exerts a bronchodilatory efficacy over 24 h in dogs and guinea pigs in the absence of systemic pharmacodynamic effects.COPDPhase 3 Clinical
  • Description
    A potent, selective long-acting β2 adrenoceptor agonist with EC50 of 1.4 nM for hβ2; shows >250 fold selectivity over hβ1; exerts a bronchodilatory efficacy over 24 h in dogs and guinea pigs in the absence of systemic pharmacodynamic effects.COPD Phase 3 Clinical
  • Synonyms
    BI1744 CL
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    β2-adrenoceptor
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    868049-49-4
  • Formula Weight
    386.44
  • Molecular Formula
    C21H26N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: 6.2 mg/mL
  • SMILES
    CC(C)(CC1=CC=C(C=C1)OC)NCC(C2=C3C(=CC(=C2)O)NC(=O)CO3)O
  • Chemical Name
    2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bouyssou T, et al. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1410-4.
2. Bouyssou T,J Pharmacol Exp Ther. 2010 Jul;334(1):53-62. et al.
3. Wex E, et al. Br J Pharmacol. 2015 Jul;172(14):3537-47.
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