Milveterol ( GSK 159797 )

Catalog No. M15483 CAS No. 652990-07-3

Milveterol (GSK 159797) is a potent, selective long-acting β2 adrenoceptor agonist with pEC50 of 10.2 in cell-based assays.

Purity : >98% (HPLC)

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Biological Information

Product Name

Milveterol
Note

Research use only, not for human use.
Brief Description

Milveterol (GSK 159797) is a potent, selective long-acting β2 adrenoceptor agonist with pEC50 of 10.2 in cell-based assays.
Description

Milveterol (GSK 159797) is a potent, selective long-acting β2 adrenoceptor agonist with pEC50 of 10.2 in cell-based assays, displays good β2/β1 selectivity (>300-fold); demonstrates high potency in vitro and long duration of action in a guinea pig model of bronchoprotection.Asthma Phase 2 Discontinued
Synonyms

GSK 159797
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

Adrenergic Receptor
Research Area

Inflammation/Immunology
Indication

Asthma

Chemical Information

CAS Number

652990-07-3
Formula Weight

435.52
Molecular Formula

C25H29N3O4
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC=C(C=C1)C(CNC2=CC=C(C=C2)CCNCC(C3=CC(=C(C=C3)O)NC=O)O)O
Chemical Name

N-(2-hydroxy-5-((R)-1-hydroxy-2-((4-(((R)-2-hydroxy-2-phenylethyl)amino)phenethyl)amino)ethyl)phenyl)formamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Jacobsen JR, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1213-8.
2. Fuso L, et al. Curr Med Chem. 2013;20(12):1477-95.
3. Jacobsen JR, et al. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2625-30.

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