Oleoylethanolamide
CAS No. 111-58-0
Oleoylethanolamide ( N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide )
Catalog No. M22670 CAS No. 111-58-0
Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 35 | In Stock |
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5MG | 58 | In Stock |
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10MG | 87 | In Stock |
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25MG | 170 | In Stock |
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50MG | 312 | In Stock |
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100MG | 500 | In Stock |
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200MG | 695 | In Stock |
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500MG | 1062 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameOleoylethanolamide
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NoteResearch use only, not for human use.
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Brief DescriptionOleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.
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DescriptionOleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.Treatment with OEA (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuated the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs).?Gene expression analysis of hepatic tissues indicated that OEA inhibited the expression of α-smooth muscle action (α-SMA) and collagen matrix, fibrosis markers, and genes involved in inflammation and extracellular matrix remodeling.?
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SynonymsN-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorHuman Endogenous Metabolite;PPARα
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Research Area——
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Indication——
Chemical Information
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CAS Number111-58-0
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Formula Weight325.53
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Molecular FormulaC20H39NO2
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Purity>98% (HPLC)
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SolubilityDMSO:19.83 mg/mL (60.92 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
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SMILESCCCCCCCC\C=C/CCCCCCCC(=O)NCCO
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen L, et al. Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells. Oncotarget. 2015 Dec 15;6(40):42530-40
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