Oleoylethanolamide

CAS No. 111-58-0

Oleoylethanolamide ( N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide )

Catalog No. M22670 CAS No. 111-58-0

Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 35 In Stock
5MG 58 In Stock
10MG 87 In Stock
25MG 170 In Stock
50MG 312 In Stock
100MG 500 In Stock
200MG 695 In Stock
500MG 1062 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Oleoylethanolamide
  • Note
    Research use only, not for human use.
  • Brief Description
    Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.
  • Description
    Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.Treatment with OEA (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuated the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs).?Gene expression analysis of hepatic tissues indicated that OEA inhibited the expression of α-smooth muscle action (α-SMA) and collagen matrix, fibrosis markers, and genes involved in inflammation and extracellular matrix remodeling.?
  • Synonyms
    N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Human Endogenous Metabolite;PPARα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    111-58-0
  • Formula Weight
    325.53
  • Molecular Formula
    C20H39NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:19.83 mg/mL (60.92 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
  • SMILES
    CCCCCCCC\C=C/CCCCCCCC(=O)NCCO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen L, et al. Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells. Oncotarget. 2015 Dec 15;6(40):42530-40
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