Oleandrin ( PBI05204; PBI 05204; PBI-05204; Oleandrin )

Catalog No. M18570 CAS No. 465-16-7

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Datasheet

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Product Name

Oleandrin
Note

Research use only, not for human use.
Brief Description

Oleandrin, the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels.
Description

Oleandrin, also known as PBI-05204 , is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically binds to and inhibits the alpha3 subunit of the Na/K-ATPase pump in human cancer cells. This may inhibit the phosphorylation of Akt, upregulate MAPK, inhibit NF-kb activation and inhibit FGF-2 export and may downregulate mTOR thereby inhibiting p70S6K and S6 protein expression. All of this may lead to an induction of apoptosis.
Synonyms

PBI05204; PBI 05204; PBI-05204; Oleandrin
Pathway

Autophagy
Target

Autophagy
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

465-16-7
Formula Weight

576.72
Molecular Formula

C32H48O9
Purity

98%
Solubility

——
SMILES

CC1C(C(CC(O1)OC2CCC3(C(C2)CCC4C3CCC5(C4(CC(C5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O
Chemical Name

(3S,5R,9S,10S,13R,14S,16S)-14-hydroxy-3-(((2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-16-yl acetate