BRD5631( BRD 5631 | BRD-5631 )

Catalog No. M16938 CAS No. ——

COA

Datasheet

HNMR

HPLC

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Product Name

BRD5631
Note

Research use only, not for human use.
Brief Description

A small-molecule enhancer of autophagy through an mTOR-independent pathway; significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs.
Description

A small-molecule enhancer of autophagy through an mTOR-independent pathway; significantly reduces the number of eGFP-HDQ74-positive cells, and increases the transcript level of p62 in Atg5+/+ MEFs; significantly reduces levels of endogenous p62 and cell death in NPC1 hiPSC-derived neurons; enhances bacterial clearance and suppresses IL-1β Secretion in an autophagy-dependent manner; a valuable tool for studying the role of autophagy in the context of cellular homeostasis and disease.
In Vitro

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In Vivo

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Synonyms

BRD 5631 | BRD-5631
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

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Indication

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CAS Number

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Formula Weight

501.627
Molecular Formula

C30H35N3O4
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(NC(C=C1)=CC2=C1OC[C@H](C)NC[C@H](C)[C@H](OC)CN(C)C2=O)C3=CC=C(C4=CC=CC=C4)C=C3
Chemical Name

N-((3S,6S,7S)-7-methoxy-3,6,9-trimethyl-10-oxo-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1]oxa[4,9]diazacyclododecin-12-yl)-[1,1'-biphenyl]-4-carboxamide

1. Kuo SY, et al. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7.

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