
Olaparib
CAS No. 763113-22-0
Olaparib( AZD2281 | KU-0059436 | KU0059436 | | AZD 2281 )
Catalog No. M15896 CAS No. 763113-22-0
A potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 28 | In Stock |
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10MG | 43 | In Stock |
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50MG | 61 | In Stock |
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100MG | 82 | In Stock |
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200MG | 108 | In Stock |
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500MG | 161 | In Stock |
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1G | 222 | In Stock |
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Biological Information
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Product NameOlaparib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.
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DescriptionA potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively; displays 300-fold selectivity over tankyrase (TNKS-1 IC50=1.5 uM); shows standalone activity against BRCA1-deficient breast cancer cell lines; regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.Ovarian Cancer Approved(In Vitro):Olaparib (AZD2281) is a single digit nanomolar inhibitor of both PARP-1 and PARP-2 that shows standalone activity against BRCA1-deficient breast cancer cell lines. Olaparib is applied to SW620 cell lysates, and identified the IC50 for PARP-1 inhibition to be around 6 nM and the total ablation of PARP-1 activity to be at concentrations of 30?100 nM.(In Vivo):Animals bearing SW620 xenografted tumors are treated with Olaparib (10 mg/kg, p.o.) in combination with NSC 362856 (TMZ) (50 mg/kg, p.o.) once daily for 5 consecutive days, after which the tumors are left to grow out. Olaparib increases vascular perfusion in Calu-6 tumors established in a DWC model. Administration of olaparib(50 mg/kg, p.o.) as a single agent (top panel) or in combination with radiation (bottom panel) results in an increase in fluorescence intensity in the Calu-6 tumors.
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In Vitro——
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In Vivo——
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SynonymsAZD2281 | KU-0059436 | KU0059436 | | AZD 2281
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorPARP1|PARP2
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Research AreaCancer
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IndicationOvarian Cancer
Chemical Information
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CAS Number763113-22-0
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Formula Weight434.4628
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Molecular FormulaC24H23FN4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 29 mg/mL
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SMILESO=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(C4CC4)=O)CC3)=O)=C2)C5=C1C=CC=C5
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Chemical Name1(2H)-Phthalazinone, 4-[[3-[[4-(cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Menear KA, et al. J Med Chem. 2008 Oct 23;51(20):6581-91.
2. Evers B, et al. Clin Cancer Res. 2008 Jun 15;14(12):3916-25.
3. Rottenberg S, et al. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84.
4. Hay T, et al. Cancer Res. 2009 May 1;69(9):3850-5.
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