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Obatoclax
CAS No. 803712-79-0
Obatoclax ( Obatoclax Mesylate;GX15-070 )
Catalog No. M16009 CAS No. 803712-79-0
A potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 113 | In Stock |
|
| 50MG | 203 | In Stock |
|
| 100MG | 340 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameObatoclax
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1.
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DescriptionA potent inhibitor of Bcl-2 family with IC50s of 1-7 uM for Bcl-2, Bcl-XL, Bcl-w, Bcl-B, Mcl-1 and Bfl-1; potently interferes with the direct interaction between MCL-1 and BAK in intact mitochondrial outer membrane and inhibited the association between MCL-1 and BAK in intact cells.
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SynonymsObatoclax Mesylate;GX15-070
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number803712-79-0
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Formula Weight413.49
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Molecular FormulaC21H23N3O4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 48.8 mg/mL
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SMILESCC1=CC(=C(N1)/C=C\2/C(=C/C(=C/3\C=C4C=CC=CC4=N3)/N2)OC)C.CS(=O)(=O)O
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Chemical Name1H-Indole, 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-, methanesulfonate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhai D, et al. Cell Death Differ. 2006 Aug;13(8):1419-21.
2. Nguyen M, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7.
3. Konopleva M, et al. Cancer Res. 2008 May 1;68(9):3413-20.
2. Nguyen M, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7.
3. Konopleva M, et al. Cancer Res. 2008 May 1;68(9):3413-20.
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