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OSU-T315
CAS No. 1333146-24-9
OSU-T315 ( OSU-T 315 )
Catalog No. M11325 CAS No. 1333146-24-9
A novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 87 | In Stock |
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| 5MG | 149 | In Stock |
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| 10MG | 194 | In Stock |
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| 25MG | 248 | In Stock |
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| 50MG | 305 | In Stock |
|
| 100MG | 444 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOSU-T315
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NoteResearch use only, not for human use.
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Brief DescriptionA novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM.
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DescriptionA novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM; exhibits high in vitro potency against a panel of prostate and breast cancer cell lines (IC50=1-2.5 uM) with no effect on normal epithelial cells; facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including GSK-3β and myosin light chain; suppresses the expression of the transcription/translation factor YB-1 and HER2, EGFR in PC-3 cells, induces autophagy and apoptosis; demonstrates in vivo efficacy in suppressing PC-3 xenograft tumor growth; orally active.
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SynonymsOSU-T 315
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorIntegrin
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1333146-24-9
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Formula Weight533.59
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Molecular FormulaC30H30F3N5O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC)CCC1=NN(C2=CC=C(N3CCNCC3)C=C2)C(C4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)=C1
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Chemical Name1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
2.Liu TM, et al. Blood. 2015 Jan 8;125(2):284-95.
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