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Home - Products - Proteasome/Ubiquitin - Proteasome - ONX-0914

ONX-0914

CAS No. 960374-59-8

ONX-0914( PR-957 | ONX 0914 | ONX0914 | PR957 | PR 957 )

Catalog No. M16857 CAS No. 960374-59-8

ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ONX-0914
  • Note
    Research use only, not for human use.
  • Brief Description
    ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM.
  • Description
    ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM, 20- to 40-fold more selective over β5 or LMP2; blocks presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo, blocks production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells; reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels in experimental arthritis models.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Collagen antibody-induced arthritis (CAIA, Arthritis was induced in BALB/c mice with antibodies specific for type II collagen (mAb) and endotoxin)Dosage:2, 6 or 10 mg per kg body weight Administration:I.v.; treated on days 4, 6 and 8 Result:Blocked disease progression in a dose-dependent manner and completely ameliorated visible signs of disease at the highest dose.
  • Synonyms
    PR-957 | ONX 0914 | ONX0914 | PR957 | PR 957
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Proteasome
  • Recptor
    LMP7
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    960374-59-8
  • Formula Weight
    580.6719
  • Molecular Formula
    C31H40N4O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 35 mg/mL
  • SMILES
    O=C(N[C@@H](CC1=CC=CC=C1)C([C@]2(C)OC2)=O)[C@@H](NC([C@@H](NC(CN3CCOCC3)=O)C)=O)CC4=CC=C(OC)C=C4
  • Chemical Name
    L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Muchamuel T, et al. Nat Med. 2009 Jul;15(7):781-7. 2. Basler M, et al. J Immunol. 2010 Jul 1;185(1):634-41. 3. Ichikawa HT, et al. Arthritis Rheum. 2012 Feb;64(2):493-503. 4. Verbrugge SE, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):174-82.
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  • ONX-0914

    ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM.

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