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Home - Products - GPCR/G Protein - Prostaglandin Receptor - ONO-1301

ONO-1301

CAS No. 176391-41-6

ONO-1301( ONO 1301 | ONO1301 )

Catalog No. M12659 CAS No. 176391-41-6

A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ONO-1301
  • Note
    Research use only, not for human use.
  • Brief Description
    A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.
  • Description
    A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase; suppresses the elevation of protein excretion into urine in rats, attenuates the development of bleomycin-induced pulmonary fibrosis and improves survival in bleomycin mice.Thrombosis Discontinued.
  • In Vitro
    ONO 1301 (ONO-AP 500-02) inhibits collagen-induced aggregation in a concentration-dependent manner, with an IC50 value of 460 nM.ONO-1301 (0-1000 nM) significantly increases alkaline phosphatase (ALP) activity in the primary osteoblasts and ST2 cells.
  • In Vivo
    ONO-1301 (6 mg/kg; p.o.; /daily for 4 weeks) improves the hemodynamic status of rats with dilated cardiomyopathy after experimental autoimmune myocarditis. Animal Model:Eight-week-old male Lewis rats (rat model of myosin-induced experimental autoimmune myocarditis)Dosage:6 mg/kg Administration:Orally; /daily for 4 weeks Result:Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved.
  • Synonyms
    ONO 1301 | ONO1301
  • Pathway
    GPCR/G Protein
  • Target
    Prostaglandin Receptor
  • Recptor
    Prostaglandin Receptor
  • Research Area
    Cardiovascular Disease
  • Indication
    Thrombosis

Chemical Information

  • CAS Number
    176391-41-6
  • Formula Weight
    428.488
  • Molecular Formula
    C26H24N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (116.69 mM)
  • SMILES
    O=C(O)COC1=C2CCC(C)=C(CCO/N=C(C3=CC=CC=C3)\C4=CC=CN=C4)C2=CC=C1
  • Chemical Name
    [7,8-dihydro-5-[(E)-[[a-(3-pyridyl)benzylidene]-aminooxy]ethyl]-1 -naphtyloxy]acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hayashi K, et al. Jpn J Pharmacol. 1997 Jan;73(1):73-82. 2. Rudd JA, et al. Br J Pharmacol. 2000 Feb;129(4):782-90. 3. Chow KB, et al. Br J Pharmacol. 2001 Dec;134(7):1375-84. 4. Murakami S, et al. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L59-65.
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