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BGC20-1531
CAS No. 1962928-26-2
BGC20-1531( PGN-1531 | AP 1531 | BGC 20-1531 )
Catalog No. M13079 CAS No. 1962928-26-2
BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 178 | Get Quote |
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| 5MG | 268 | Get Quote |
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| 10MG | 408 | Get Quote |
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| 25MG | 673 | Get Quote |
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| 50MG | 945 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBGC20-1531
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NoteResearch use only, not for human use.
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Brief DescriptionBGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist.
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DescriptionBGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8); shows no appreciable affinity at a wide range of other receptors (including other prostanoid receptors), channels, transporters and enzymes (pKi < 5); competitively antagonizes PGE(2)-induced vasodilatation of human middle cerebral (pK(B) 7.8) and meningeal (pK(B) 7.6) arteries in vitro, and PGE(2)-induced increase in canine carotid blood flow in vivo.Migraine Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsPGN-1531 | AP 1531 | BGC 20-1531
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorProstaglandin Receptor
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Research AreaNeurological Disease
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IndicationMigraine
Chemical Information
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CAS Number1962928-26-2
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Formula Weight529.004
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Molecular FormulaC26H25ClN2O6S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(O2)C)COC3=CC=C(C=C3)C4=NC=C(C=C4)OC.Cl
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Chemical Name4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Maubach KA, et al. Br J Pharmacol. 2009 Jan;156(2):316-27.
2. Antonova M, et al. J Headache Pain. 2011 Oct;12(5):551-9.
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