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Home - Products - Nuclear Receptor/Transcription Factor - Progesterone Receptor - Nomegestrol

Nomegestrol

CAS No. 58691-88-6

Nomegestrol( —— )

Catalog No. M33634 CAS No. 58691-88-6

Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nomegestrol
  • Note
    Research use only, not for human use.
  • Brief Description
    Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.
  • Description
    Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
  • In Vitro
    Nomegestrol is a progestin, has high binding affinity at progesterone receptor, with a Kd of 5.44 nM for rat uterine progesterone receptor. Nomegestrol acetate (NOMAC) is a higly selective progesterone receptor full agonist, but shows no or little binding affinity at other steroid receptors, such as the androgen and glucocorticoid receptors. Nomegestrol acetate has moderate antiandrogenic activity and strong antiestrogenic activity.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    Progesterone Receptor
  • Recptor
    Progesterone Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    58691-88-6
  • Formula Weight
    328.45
  • Molecular Formula
    C21H28O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@@]12[C@]([C@]3([C@@]([C@@]4(C(C(C)=C3)=CC(=O)CC4)[H])(CC1)[H])[H])(CC[C@@]2(C(C)=O)O)[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Duc I, et al. Interaction of [3H]nomegestrol acetate with cytosolic progesterone receptors from the rat uterus. Steroids. 1991 Jun;56(6):325-8.?
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