Nitrosoglutathione

CAS No. 57564-91-7

Nitrosoglutathione( GSNO | SNOG | S-Nitrosoglutathione | Glutathione thionitrite )

Catalog No. M27194 CAS No. 57564-91-7

GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 43 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Nitrosoglutathione
  • Note
    Research use only, not for human use.
  • Brief Description
    GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.
  • Description
    GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.(In Vitro):GSNO completely abolished the AngII-dependent AT1 receptor-mediated vasoconstriction of cerebral arteries. GSNO had no impact on responses to other vasoconstrictors sharing (phenylephrine, U46619) or not (5-HT) the same signalling pathway. (In Vivo):Elevated blood pressure, proteinuria, and intrauterine growth restriction associated with PE were induced in Sprague-Dawley rats using L-NAME. These were partially reversed with the use of GSNO.
  • In Vitro
    Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity.
  • In Vivo
    Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20.Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, but up-regulates endothelial NOS expression in the flap vessels. Animal Model:Male Lewis rats.Dosage:0.2 and 0.6 mg/kg.Administration:Slow intravenous injection via the opposite femoral vein into each rat.Result:Animals treated with 0.2 mg of GSNO per kilogram before reperfusion had an intermediate survival rate (40.2 ± 4.9%). Although 0.6 mg/kg of GSNO showed a better rescuing effect than 150 mg/kg of NAC, there was no significant difference between the groups.
  • Synonyms
    GSNO | SNOG | S-Nitrosoglutathione | Glutathione thionitrite
  • Pathway
    Endocrinology/Hormones
  • Target
    RAAS
  • Recptor
    PI3Kδ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    57564-91-7
  • Formula Weight
    336.32
  • Molecular Formula
    C10H16N4O7S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 25 mg/mL (74.33 mM)
  • SMILES
    N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Daniel P. Gold, et al. Combination therapy. WO2019183226A1.
molnova catalog
related products
  • Theasinensin C

    Theasinensin C is a compound extracted from black tea water with an IC50 value of 40.21 μM for renin activity.

  • Telmisartan

    Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

  • Plantainoside D

    Plantainoside D shows potent antioxidative effects as those of ascorbic acid it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM it also shows inhibitory activity against PKCalpha with the IC50 value14.8microM.?