Telmisartan ( BIBR 277; Micardis; Pritor )

Catalog No. M11907 CAS No. 144701-48-4

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Product Name

Telmisartan
Note

Research use only, not for human use.
Brief Description

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
Description

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Synonyms

BIBR 277; Micardis; Pritor
Pathway

Endocrinology/Hormones
Target

RAAS
Recptor

angiotensin II type 1 receptor
Research Area

Cardiovascular Disease
Indication

——

CAS Number

144701-48-4
Formula Weight

514.62
Molecular Formula

C33H30N4O2
Purity

>98%(HPLC)
Solubility

DMSO: 13 mg/mL (25.26 mM)
SMILES

O=C(C1=CC=CC=C1C2=CC=C(CN3C4=CC(C5=NC6=CC=CC=C6N5C)=CC(C)=C4N=C3CCC)C=C2)O
Chemical Name

4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid

1.Benson SC, et al. Hypertension, 2004, 43(5), 993-1002.

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