Nicorandil ( 2-Nicotinamidoethyl nitrate; SG-75 )

Catalog No. M15474 CAS No. 65141-46-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Nicorandil
Note

Research use only, not for human use.
Brief Description

Nicorandil(Ikorel)is potassium channel activator. It acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system.
Description

Nicorandil(Ikorel)is potassium channel activator. It acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It does this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.
Synonyms

2-Nicotinamidoethyl nitrate; SG-75
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

Potassium Channel
Research Area

Cardiovascular Disease
Indication

——

CAS Number

65141-46-0
Formula Weight

211.18
Molecular Formula

C8H9N3O4
Purity

>98%(HPLC)
Solubility

Ethanol: 42 mg/mL (198.89 mM); Water: 17 mg/mL (80.5 mM); DMSO: 42 mg/mL (198.89 mM)
SMILES

O=[N+]([O-])OCCNC(C1=CN=CC=C1)=O
Chemical Name

2-Nicotinamidoethyl nitrate

1.Kandabashi T, et al. Circulation. 2000 Mar 21;101(11):1319-23.

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