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Neuropathiazol

CAS No. 880090-88-0

Neuropathiazol( —— )

Catalog No. M33442 CAS No. 880090-88-0

Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Neuropathiazol
  • Note
    Research use only, not for human use.
  • Brief Description
    Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells.
  • Description
    Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells.
  • In Vitro
    Neuropathiazol (5-15 μM; 5 hours) significantly slows cell proliferation without visible cytotoxic effects.Neuropathiazol (10 μM; 1-4 days) down-regulates Sox2 (a neural progenitor marker) and up-regulates NeuroD1 (a neuronal cell marker). Neuropathiazol also inhibits astroglial differentiation that is induced by LIF and BMP2.Neuropathiazol induces neuronal differentiation of multipotent adult hippocampal neural progenitor cells.Neuropathiazol can competitively suppress astrogliogenesis by LIF/BMP2/FBS in a dose-dependent manner.Cell Proliferation Assay Cell Line:HCN cells Concentration:5 μM, 10 μM, 15 μM Incubation Time:5 hours Result:Inhibited proliferation of HCN neural progenitor cells.RT-PCR Cell Line:HCN cells Concentration:10 μM Incubation Time:1 day, 4 days Result:Downregulated Sox2 and upregulated NeuroD1.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    880090-88-0
  • Formula Weight
    338.42
  • Molecular Formula
    C19H18N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (98.49 mM; Ultrasonic )
  • SMILES
    CCOC(=O)C1=CC=C(C=C1)N(C)C1=CSC(=N1)C1=CC=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Warashina M, et al. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16;45(4):591-3.?
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