SRT3109

Research use only, not for human use.

SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.

SRT3109 is a CXCR2 ligand. CXCR2 ligands are potent chemoattractants for neutrophils and play a key role in the emigration of neutrophils from the blood to sites of tissue inflammation. Moreover, CXCR2 signaling may also regulate neutrophil mobilization from the bone marrow. Deletion of the chemokine receptor CXCR2 prevents the recruitment of neutrophils into tissues and subsequent development of experimental Lyme arthritis.

SRT3109 (Example 1) is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases.

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SRT3109 | SRT-3109

Others

Other Targets

CXCR2

Inflammation/Immunology

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1204707-71-0

475.53

C18H23F2N5O4S2

>98% (HPLC)

DMSO : ≥ 100 mg/mL; 210.29 mM

C[C@H]([C@H](CO)O)Nc1cc(nc(n1)SCc1c(c(ccc1)F)F)NS(=O)(=O)N1CCC1

N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3R)-3,4-dihydroxybutan-2-yl)amino)pyrimidin-4-yl)azetidine-1-sulfonamide

(-20℃)

With Ice Pack

≥ 2 years