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Netarsudil
CAS No. 1254032-66-0
Netarsudil( AR-13324 )
Catalog No. M11024 CAS No. 1254032-66-0
Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1233 | Get Quote |
|
| 50MG | 2502 | Get Quote |
|
| 100MG | 3330 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNetarsudil
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NoteResearch use only, not for human use.
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Brief DescriptionNetarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.
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DescriptionNetarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; 11 kinases are inhibited >90% in a panel of 422 kinases, only ROCK1 and ROCK2 (each 93% inhibition) and PKC (delta, 91%, and eta, 93% inhibition); exhibts improved bioavailability, demonstrates an effective and sustained IOP reduction for 24h after dosing; a novel ocular hypotensive agent for the treatment of glaucoma.Other Indication Approved.
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In Vitro——
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In Vivo——
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SynonymsAR-13324
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1254032-66-0
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Formula Weight453.54
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Molecular FormulaC28H27N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C
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Chemical Name(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80.
2. Li G, et al. Eur J Pharmacol. 2016 Sep 15;787:20-31.
3. Lin CW, et al. J Ocul Pharmacol Ther. 2017 Jun 13. doi: 10.1089/jop.2017.0023.
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Netarsudil
Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2.
