Nesiritide
CAS No. 124584-08-3
Nesiritide ( Brain Natriuretic Peptide-32 human; BNP-32 )
Catalog No. M29907 CAS No. 124584-08-3
Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 761 | Get Quote |
|
10MG | 1158 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
Biological Information
-
Product NameNesiritide
-
NoteResearch use only, not for human use.
-
Brief DescriptionNesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.
-
DescriptionNesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.(In Vitro):Nesiritide is an agonist of natriuretic peptide receptor (NPR), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. ProBNP1-108 stimulates guanylyl cyclase-A (GC-A) to near-maximum activities but is 13-fold less potent than Nesiritide (BNP1-32). ProBNP1-108 binds human GC-A 35-fold less tightly than Nesiritide. Neither proBNP1–108 nor Nesiritide activates GC-B. The natriuretic peptide clearance receptor binds proBNP1-108 3-fold less tightly than Nesiritide. The half time for degradation of proBNP1-108 by human kidney membranes is 2.7-fold longer than for Nesiritide, and the time required for complete degradation is 6-fold longer. Nesiritide and proBNP1-108 are best fitted by first- and second-order exponential decay models, respectively.
-
SynonymsBrain Natriuretic Peptide-32 human; BNP-32
-
PathwayOthers
-
TargetOther Targets
-
RecptorKd: 7.3 Pm (NPR-A), 13 pM (NPR-C)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number124584-08-3
-
Formula Weight3464
-
Molecular FormulaC143H244N50O42S4
-
Purity>98% (HPLC)
-
SolubilityH2O : ≥ 40 mg/mL (11.55 mM)
-
SMILES——
-
Chemical Name
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
Koller KJ, et al. Molecular biology of the natriuretic peptides and their receptors. Circulation. 1992 Oct;86(4):1081-8.
molnova catalog
related products
-
Aficamten
Aficamten is a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.
-
5-Bromo-1H-Indole-3-...
5-Bromo-1H-Indole-3-Carboxylic Acid Methyl Ester is a marine derived natural products found in Smenospongia sp.
-
19 alpha-Hydroxyasia...
19 alpha-Hydroxyasiatic acid shows significant anticoagulant effect on the extrinsic pathway.