Nesiritide

CAS No. 124584-08-3

Nesiritide ( Brain Natriuretic Peptide-32 human; BNP-32 )

Catalog No. M29907 CAS No. 124584-08-3

Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Nesiritide
  • Note
    Research use only, not for human use.
  • Brief Description
    Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.
  • Description
    Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.(In Vitro):Nesiritide is an agonist of natriuretic peptide receptor (NPR), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. ProBNP1-108 stimulates guanylyl cyclase-A (GC-A) to near-maximum activities but is 13-fold less potent than Nesiritide (BNP1-32). ProBNP1-108 binds human GC-A 35-fold less tightly than Nesiritide. Neither proBNP1–108 nor Nesiritide activates GC-B. The natriuretic peptide clearance receptor binds proBNP1-108 3-fold less tightly than Nesiritide. The half time for degradation of proBNP1-108 by human kidney membranes is 2.7-fold longer than for Nesiritide, and the time required for complete degradation is 6-fold longer. Nesiritide and proBNP1-108 are best fitted by first- and second-order exponential decay models, respectively.
  • Synonyms
    Brain Natriuretic Peptide-32 human; BNP-32
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Kd: 7.3 Pm (NPR-A), 13 pM (NPR-C)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    124584-08-3
  • Formula Weight
    3464
  • Molecular Formula
    C143H244N50O42S4
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : ≥ 40 mg/mL (11.55 mM)
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Koller KJ, et al. Molecular biology of the natriuretic peptides and their receptors. Circulation. 1992 Oct;86(4):1081-8.
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