Nepodin
CAS No. 3785-24-8
Nepodin ( —— )
Catalog No. M22053 CAS No. 3785-24-8
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 222 | In Stock |
|
10MG | 357 | In Stock |
|
25MG | 587 | In Stock |
|
50MG | 822 | In Stock |
|
100MG | 1107 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameNepodin
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NoteResearch use only, not for human use.
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Brief DescriptionNepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity.
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DescriptionNepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin.To obtain a novel modulator of glucose metabolism, we conducted screening of a small compound library in cultured L6 myotubes. We identified Nepodin that stimulated glucose uptake dose-dependently in differentiated L6 myotubes. The stimulatory effect of Nepodin on glucose uptake was abrogated by a 5'-adenosine monophosphate-activated protein kinase (AMPK) inhibitor. In addition, Nepodin stimulated the phosphorylation of AMPK. Nepodin also stimulated the translocation of GLUT4 to the plasma membrane in L6 myoblasts transfected with a Glut4 cDNA-coding vector and in differentiated L6 myotubes. In in vivo study, Nepodin suppressed the increases in fasting blood glucose levels and improved the glucose intolerance of C57BL/KsJ-db/db mice, a type 2 diabetic animal model. Nepodin rescued the impaired phosphorylation of AMPK in the skeletal muscle of db/db mice.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX;AMPK;GLUT
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Research Area——
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Indication——
Chemical Information
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CAS Number3785-24-8
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Formula Weight216.23
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Molecular FormulaC13H12O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(=O)C1=C(O)C2=C(C=CC=C2O)C=C1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo.Biofactors. 2014 Jul-Aug;40(4):436-47.
molnova catalog
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