COX-2-IN-34

Research use only, not for human use.

COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.

COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects.

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Animal Model:The Carrageenan-induced rat paw edema assay model Dosage:50 mg/kg Administration:Subcutaneous injection (s.c.)Result:Expressed the reduction of edema claw volume after 0h, 1 h, 2 h, 3h, 4 h, and 6 h of carrageenan injection compared to the control group. Exhibited superior inhibition of 42.90% and 45.95% at the 3rd and 4th hour, respectively, which was comparatively much closer in potency to that of the Celecoxib (HY-14398) group (45.18% inhibition of edema at 3h).

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Chromatin/Epigenetic

COX

COX

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2788578-71-0

245.23

C13H11NO4

>98% (HPLC)

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C(NC1=C(O)C=CC=C1)(=O)C2=C(O)C(O)=CC=C2

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(-20℃)

With Ice Pack

≥ 2 years