Nef-IN-B9 ( Nef inhibitor B9 )

Catalog No. M12024 CAS No. 1473404-51-1

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Product Name

Nef-IN-B9
Note

Research use only, not for human use.
Brief Description

Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM.
Description

Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM; also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn; blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells; binds directly to Nef with Kd of 1.79 nM.
Synonyms

Nef inhibitor B9
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

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Indication

——

CAS Number

1473404-51-1
Formula Weight

402.81
Molecular Formula

C16H11ClN6O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

(E)-4-((3-chlorophenyl)diazenyl)-5-hydroxy-3-(4-nitrophenyl)-1H-pyrazole-1-carbothioamide

1. Emert-Sedlak LA, et al. Chem Biol. 2013 Jan 24;20(1):82-91.

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