Nedocromil

Research use only, not for human use.

Nedocromil (FPL59002) is a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase.

Nedocromil (FPL59002) is a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes.Allergy Approved.

Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively).

Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function.

FPL 59002 | FPL59002

GPCR/G Protein

Leukotriene Receptor

Leukotriene Receptor

Inflammation/Immunology

Allergy

69049-73-6

371.3408

C19H17NO7

>98% (HPLC)

DMSO: 15 mg/mL

O=C(C1=CC(C2=CC3=C(N(CC)C(C(O)=O)=CC3=O)C(CCC)=C2O1)=O)O

4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-

(-20℃)

With Ice Pack

≥ 2 years