Necrosulfonamide

Research use only, not for human use.

A small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation.

A small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation; binds within the N-terminal 178 residues of human MLKL; arrests necrosis at a specific step at which RIP3 formed discrete punctae in cells.(In Vitro):Necrosulfonamide specifically blocks necrosis downstream of RIP3 activation. Necrosulfonamide inhibits MLKL-mediated necrosis by blocking Its N-terminal CC domain function.

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MAPK/ERK Signaling

MLK

necrosis(MLKL)

Cancer

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1360614-48-7

461.4716

C18H15N5O6S2

>98% (HPLC)

DMSO: ≥ 28 mg/mL

COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]

2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)-

(-20℃)

With Ice Pack

≥ 2 years