Cart
sales@molnova.com
Necrostatin-1
CAS No. 4311-88-0
Necrostatin-1( Nec-1 )
Catalog No. M14462 CAS No. 4311-88-0
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 27 | In Stock |
|
| 10MG | 42 | In Stock |
|
| 25MG | 77 | In Stock |
|
| 50MG | 132 | In Stock |
|
| 100MG | 164 | In Stock |
|
| 200MG | 246 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNecrostatin-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionNecrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
-
DescriptionNecrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
-
In Vitro——
-
In Vivo——
-
SynonymsNec-1
-
PathwayApoptosis
-
TargetTNF
-
RecptorRIP1
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number4311-88-0
-
Formula Weight259.33
-
Molecular FormulaC13H13N3OS
-
Purity>98% (HPLC)
-
SolubilityDMSO: 51 mg/mL warmed (196.66 mM)
-
SMILESO=C(C(CC1=CNC2=C1C=CC=C2)N3)N(C)C3=S
-
Chemical Name5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Han W, et al. Apoptosis. 2009 May;14(5):674-86.
molnova catalog
related products
-
MOSLOFLAVONE
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and ?7.8 μM respectively.
-
TNF-α-IN-9
TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.
-
Certolizumab pegol
Certolizumab pegol (Certolizumab) is a polyethylene glycolated and humanized anti-TNF-α monoclonal antibody for the study of autoimmune diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).
