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Navitoclax

CAS No. 923564-51-6

Navitoclax ( ABT-263;ABT 263;ABT263 )

Catalog No. M16614 CAS No. 923564-51-6

Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 37 In Stock
10MG 51 In Stock
25MG 79 In Stock
50MG 133 In Stock
100MG 177 In Stock
200MG 259 In Stock
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Biological Information

  • Product Name
    Navitoclax
  • Note
    Research use only, not for human use.
  • Brief Description
    Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w.
  • Description
    Navitoclax (ABT-263) is a potent, orally bioavailable Bcl-2 family inhibitor with Ki of <1 nM for Bcl-2, Bcl-xL, and Bcl-w; binds more weakly to Mcl-1 and A1 (Ki>350 nM); disrupts Bcl-2/Bcl-xL interactions with pro-death proteins (e.g., Bim), induces apoptosis, shows cellular activity against a panel of human tumor cell lines (EC50<1 uM); induces complete tumor regressions in xenograft models of NSCLA and ALL.Blood Cancer Phase 2 Clinical
  • Synonyms
    ABT-263;ABT 263;ABT263
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2;Bcl-w;Bcl-xL
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    923564-51-6
  • Formula Weight
    974.61
  • Molecular Formula
    C47H55ClF3N5O6S3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NS(=O)(C1=CC=C(N[C@H](CCN2CCOCC2)CSC3=CC=CC=C3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4
  • Chemical Name
    Benzamide, 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tse C, et al. Cancer Res. 2008 May 1;68(9):3421-8.
2. Shoemaker AR, et al. Clin Cancer Res. 2008 Jun 1;14(11):3268-77.
3. Ackler S, et al. Mol Cancer Ther. 2008 Oct;7(10):3265-74.
4. Shah OJ, et al. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12634-9.
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