MIK665 ( S-64315;MIK-665;S64315 )

Catalog No. M12722 CAS No. 1799631-75-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MIK665
Note

Research use only, not for human use.
Brief Description

MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor with potential pro-apoptotic and antineoplastic activities.
Description

MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor with potential pro-apoptotic and antineoplastic activities; binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.Blood Cancer Phase 1 Clinical
Synonyms

S-64315;MIK-665;S64315
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

Cancer
Indication

Blood cancer

CAS Number

1799631-75-6
Formula Weight

875.41
Molecular Formula

C47H44ClFN6O6S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 125 mg/mL 142.79 mM; H2O : < 0.1 mg/mL
SMILES

O=C(O)[C@@H](CC1=C(OCC2=NC(C3=C(OC)C=CC=C3)=NC=C2)C=CC=C1)OC4=C5C(SC(C6=CC=C(F)C=C6)=C5C7=C(C)C(Cl)=C(OCCN8CCN(C)CC8)C=C7)=NC=N4
Chemical Name

(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid

1. Cassier PA, et al. Br J Cancer. 2017 Oct 10;117(8):1089-1098.

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