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Napabucasin

CAS No. 83280-65-3

Napabucasin( BBI-608 )

Catalog No. M16087 CAS No. 83280-65-3

Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Napabucasin
  • Note
    Research use only, not for human use.
  • Brief Description
    Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
  • Description
    Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM); blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells; significantly reduces the expression of various stemness genes, including Nanog, Sox2, and Oct4 (POU5F1); significantly inhibits PaCa-2 xenograft tumor growth, and inhibits cancer relapse and metastasis.Colon Cancer Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BBI-608
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT3
  • Research Area
    Cancer
  • Indication
    Colon Cancer

Chemical Information

  • CAS Number
    83280-65-3
  • Formula Weight
    240.2109
  • Molecular Formula
    C14H8O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3
  • Chemical Name
    Naphtho[2,3-b]furan-4,9-dione, 2-acetyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li Y, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44. 2. Zhang Y, et al. Cancer Med. 2016 Jun;5(6):1251-8. 3. Hubbard JM, et al. Drugs. 2017 Jul;77(10):1091-1103.
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