Cart
sales@molnova.com
Napabucasin
CAS No. 83280-65-3
Napabucasin( BBI-608 )
Catalog No. M16087 CAS No. 83280-65-3
Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | In Stock |
|
| 10MG | 77 | In Stock |
|
| 50MG | 186 | In Stock |
|
| 100MG | 332 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNapabucasin
-
NoteResearch use only, not for human use.
-
Brief DescriptionNapabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
-
DescriptionNapabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM); blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells; significantly reduces the expression of various stemness genes, including Nanog, Sox2, and Oct4 (POU5F1); significantly inhibits PaCa-2 xenograft tumor growth, and inhibits cancer relapse and metastasis.Colon Cancer Phase 3 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsBBI-608
-
PathwayJAK/STAT Signaling
-
TargetSTAT
-
RecptorSTAT3
-
Research AreaCancer
-
IndicationColon Cancer
Chemical Information
-
CAS Number83280-65-3
-
Formula Weight240.2109
-
Molecular FormulaC14H8O4
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3
-
Chemical NameNaphtho[2,3-b]furan-4,9-dione, 2-acetyl-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Li Y, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44.
2. Zhang Y, et al. Cancer Med. 2016 Jun;5(6):1251-8.
3. Hubbard JM, et al. Drugs. 2017 Jul;77(10):1091-1103.
molnova catalog
related products
-
Guanosine
Guanosine is a purine nucleoside formed from a beta-N9-glycosidic bond between guanine and a ribose ring and is essential for metabolism.
-
BTA-9881
BTA-9881 is a novel RSV fusion inhibitor with oral activity and antiviral activity for the study of respiratory syncytial virus infections.
-
STAT5 inhibitor 17f
A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.
