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Napabucasin
CAS No. 83280-65-3
Napabucasin( BBI-608 )
Catalog No. M16087 CAS No. 83280-65-3
Napabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | In Stock |
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| 10MG | 77 | In Stock |
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| 50MG | 186 | In Stock |
|
| 100MG | 332 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNapabucasin
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NoteResearch use only, not for human use.
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Brief DescriptionNapabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM).
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DescriptionNapabucasin (BBI-608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM); blocks spherogenesis of cancer stem cells (CSC), but not hematopoietic stem cells; significantly reduces the expression of various stemness genes, including Nanog, Sox2, and Oct4 (POU5F1); significantly inhibits PaCa-2 xenograft tumor growth, and inhibits cancer relapse and metastasis.Colon Cancer Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsBBI-608
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT3
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Research AreaCancer
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IndicationColon Cancer
Chemical Information
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CAS Number83280-65-3
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Formula Weight240.2109
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Molecular FormulaC14H8O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3
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Chemical NameNaphtho[2,3-b]furan-4,9-dione, 2-acetyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li Y, et al. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44.
2. Zhang Y, et al. Cancer Med. 2016 Jun;5(6):1251-8.
3. Hubbard JM, et al. Drugs. 2017 Jul;77(10):1091-1103.
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