NVP-LCQ195
CAS No. 902156-99-4
NVP-LCQ195 ( LCQ-195; AT9311 )
Catalog No. M29600 CAS No. 902156-99-4
NVP-LCQ195 (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 147 | Get Quote |
|
10MG | 222 | Get Quote |
|
25MG | 425 | Get Quote |
|
50MG | 624 | Get Quote |
|
100MG | 889 | Get Quote |
|
500MG | 1782 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameNVP-LCQ195
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NoteResearch use only, not for human use.
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Brief DescriptionNVP-LCQ195 (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
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DescriptionNVP-LCQ195 (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).(In Vitro):NVP-LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-1 mol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. In MM cells, LCQ195 triggered decreased amplitude of transcriptional signatures associated with oncogenesis, drug resistance and stem cell renewal, including signatures of activation of key transcription factors for MM cells e.g. myc, HIF-1a, IRF4.(In Vivo):Bortezomib-treated MM patients whose tumours had high baseline expression of genes suppressed by LCQ195 had significantly shorter progression-free and overall survival than those with low levels of these transcripts in their MM cells.
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SynonymsLCQ-195; AT9311
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number902156-99-4
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Formula Weight460.3
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Molecular FormulaC17H19Cl2N5O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESCS(=O)(=O)N1CCC(CC1)NC(=O)c1[nH]ncc1NC(=O)c1c(Cl)cccc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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