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NVP-CGM097

CAS No. 1313363-54-0

NVP-CGM097 ( CGM097 )

Catalog No. M23472 CAS No. 1313363-54-0

NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 105 In Stock
5MG 195 In Stock
10MG 323 In Stock
25MG 534 In Stock
50MG 777 In Stock
100MG 1071 In Stock
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Biological Information

  • Product Name
    NVP-CGM097
  • Note
    Research use only, not for human use.
  • Brief Description
    NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
  • Description
    NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
  • Synonyms
    CGM097
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    E1/E2/E3 Enzyme;MDM2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1313363-54-0
  • Formula Weight
    659.3
  • Molecular Formula
    C38H47ClN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:48 mg/mL (72.81 mM);Water:Insoluble
  • SMILES
    O=C1N(C2=CC=C(N(C)C[C@H]3CC[C@H](N4CC(N(C)CC4)=O)CC3)C=C2)[C@@H](C5=CC=C(Cl)C=C5)C6=C(C=C(OC)C(OC(C)C)=C6)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Holzer P, et al. Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58(16):6348-58
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