NVP-2 ( NVP2;NVP 2;CDK9 inhibitor )

Catalog No. M11103 CAS No. 1263373-43-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

NVP-2
Note

Research use only, not for human use.
Brief Description

NVP-2 is apotent, selective, ATP-competitive CDK9 inhibitor with IC50 of <0.514 nM (CDK9/CyclinT).
Description

NVP-2 is apotent, selective, ATP-competitive CDK9 inhibitor with IC50 of <0.514 nM (CDK9/CyclinT); displays excellent kinome selectivity against a panel of 468 kinases, including CDK7 (IC50>10 uM) and CDK13; inhibits proliferation of MOLT4 cells with IC50 of 9 nM, inhibits phosphorylation of RNA Pol II CTD residues serine 2, 5 and 7, induces significant reductions in the mRNA levels of MYB and RUNX1 in MOLT4 cells.
Synonyms

NVP2;NVP 2;CDK9 inhibitor
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

1263373-43-8
Formula Weight

513.08
Molecular Formula

C27H37ClN6O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 194.91 mM
SMILES

N#CC1(CNC2=NC(C3=CC(N[C@H]4CC[C@H](N[C@H](C)COC)CC4)=NC=C3Cl)=CC=C2)CCOCC1
Chemical Name

4-(((2'-chloro-5'-(((1R,4r)-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)-[2,3'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile

1. Olson CM, et al. Nat Chem Biol. 2017 Dec 18. doi: 10.1038/nchembio.2538.

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