NUC-7738( —— )

Catalog No. M37192 CAS No. 2348493-39-8

NUC-7738 is a 5'-aryloxyphosphoamidate prodrug of 3'-dA that reduces β-catenin nuclear expression in AML cells, modulates β-catenin signaling, and can be used in cancer research.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

NUC-7738
Note

Research use only, not for human use.
Brief Description

NUC-7738 is a 5'-aryloxyphosphoamidate prodrug of 3'-dA that reduces β-catenin nuclear expression in AML cells, modulates β-catenin signaling, and can be used in cancer research.
Description

NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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Chemical Information

CAS Number

2348493-39-8
Formula Weight

568.52
Molecular Formula

C26H29N6O7P
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (175.90 mM; Ultrasonic )
SMILES

O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OC4=CC=CC=C4)(N[C@H](C(OCC5=CC=CC=C5)=O)C)=O)C1
Chemical Name

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Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Serpi M, et, al. Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3'-Deoxyadenosine, as a Potential Anticancer Agent. J Med Chem. 2022 Dec 8;65(23):15789-15804.?

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