BMS-986205 is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.

The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus.

Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruses, capable of reducing West Nile virus (WNV) protease activity by 54%.