Cart
sales@molnova.com
NU-6102
CAS No. 444722-95-6
NU-6102 ( NU6102;NU 6102 )
Catalog No. M14521 CAS No. 444722-95-6
A potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameNU-6102
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
-
DescriptionA potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively; exhibits synergistic growth inhibition, and enhanced cytotoxicity in HT29 cells in vitro and HT29 tumour growth inhibition in vivo combined with Pictilisib; induces G2 arrest, inhibition of Rb phosphorylation and cytotoxicity in SKUT-1B cells (LC50=2.6 uM, for a 24h exposure).
-
SynonymsNU6102;NU 6102
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorCDK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number444722-95-6
-
Formula Weight402.50
-
Molecular FormulaC18H22N6O3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=S(C1=CC=C(NC2=NC(OCC3CCCCC3)=C4N=CNC4=N2)C=C1)(N)=O
-
Chemical NameN-((3R,6S,9S,12R)-6-ethyl-9-(3-guanidinopropyl)-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclohexadecan-12-yl)isobutyramide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hardcastle IR, et al. J Med Chem. 2004 Jul 15;47(15):3710-22.
2. Beale G, et al. Br J Cancer. 2016 Sep 6;115(6):682-90.
3. Thomas HD, et al. Eur J Cancer. 2011 Sep;47(13):2052-9.
2. Beale G, et al. Br J Cancer. 2016 Sep 6;115(6):682-90.
3. Thomas HD, et al. Eur J Cancer. 2011 Sep;47(13):2052-9.
molnova catalog
related products
-
Dalpiciclib
Dalpiciclib is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4?nM and 9.9?nM, respectively.
-
THZ1 2HCl
THZ1 2HCl is a selective, covalent, and allosteric inhibitor of CDK7 with an IC50 of 3.2 nM. THZ1 2HCl has antiproliferative effects on a variety of cancer cell lines.
-
CDK4-IN-1
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM.
