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NU-6102
CAS No. 444722-95-6
NU-6102 ( NU6102;NU 6102 )
Catalog No. M14521 CAS No. 444722-95-6
A potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNU-6102
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NoteResearch use only, not for human use.
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Brief DescriptionA potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively.
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DescriptionA potent CDK1 and CDK2 inhibitor with IC50 of 9.5 nM and 5.4 nM against CDK1/cyclinB and CDK2/cyclinA3 respectively; exhibits synergistic growth inhibition, and enhanced cytotoxicity in HT29 cells in vitro and HT29 tumour growth inhibition in vivo combined with Pictilisib; induces G2 arrest, inhibition of Rb phosphorylation and cytotoxicity in SKUT-1B cells (LC50=2.6 uM, for a 24h exposure).
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SynonymsNU6102;NU 6102
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number444722-95-6
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Formula Weight402.50
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Molecular FormulaC18H22N6O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=S(C1=CC=C(NC2=NC(OCC3CCCCC3)=C4N=CNC4=N2)C=C1)(N)=O
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Chemical NameN-((3R,6S,9S,12R)-6-ethyl-9-(3-guanidinopropyl)-12-methyl-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclohexadecan-12-yl)isobutyramide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hardcastle IR, et al. J Med Chem. 2004 Jul 15;47(15):3710-22.
2. Beale G, et al. Br J Cancer. 2016 Sep 6;115(6):682-90.
3. Thomas HD, et al. Eur J Cancer. 2011 Sep;47(13):2052-9.
2. Beale G, et al. Br J Cancer. 2016 Sep 6;115(6):682-90.
3. Thomas HD, et al. Eur J Cancer. 2011 Sep;47(13):2052-9.
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