
NSC87877
CAS No. 56932-43-5
NSC87877( —— )
Catalog No. M18830 CAS No. 56932-43-5
NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 59 | In Stock |
![]() ![]() |
10MG | 85 | In Stock |
![]() ![]() |
25MG | 176 | In Stock |
![]() ![]() |
50MG | 293 | In Stock |
![]() ![]() |
100MG | 437 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameNSC87877
-
NoteResearch use only, not for human use.
-
Brief DescriptionNSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively.
-
DescriptionNSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
-
In VitroNSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines.NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation. Cell Viability Assay Cell Line:p53 wild-type neuroblastoma (NB) cell lines.Concentration:0, 0.25, 0.5 μM.Incubation Time:5 days.Result:Resulted in increased p53 phosphorylation (Ser37 and Ser46) and activation, increased activation of downstream p38 effector proteins (heat shock protein 27 (HSP27) and MAP kinase-activated protein kinase 2 (MAPKAPK2)) and poly ADP ribose polymerase/caspase-3 cleavage.Inhibited DUSP26 function in NB cell lines.Resulted in apoptosis in many cell lines at varying IC50 levels of 1.84 μM (IMR32), 6.35 μM (SK-N-SH), 8.69 μM (NB-19), 12.6 μM (SMS-KCN), 15.7 μM (SH-SY5Y), 15.8 μM (JF) and 19.0 μM (CHLA-225), respectively.
-
In VivoNSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity. Animal Model:Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice.Dosage:30 mg/kg. Administration:IP once daily for 15 days.Result:Significantly inhibited NB tumor growth.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorSHP-2|SHP-1
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number56932-43-5
-
Formula Weight503.42
-
Molecular FormulaC19H13N3O7S2·2Na
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (248.30 mM)
-
SMILESC1=CC2=C(C(=O)/C(=N/NC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)[O-])/C=C2S(=O)(=O)[O-])N=C1.[Na+].[Na+]
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog



related products
-
RRX-001
RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity.
-
3,5,6-trihydroxysito...
3,5,6-trihydroxysitostane is a steroid natural product derived from the fruits of Evodia rutaecarpa.
-
Palatinitol
Palatinitol is a mixture of 16-mannitol glucopyranoside and 16-sorbitol glucopyranoside.