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Home - Products - Apoptosis - MDM2-p53 - NSC-66811

NSC-66811

CAS No. 6964-62-1

NSC-66811( NSC66811 | NSC 66811 )

Catalog No. M15667 CAS No. 6964-62-1

A potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 36 Get Quote
5MG 58 Get Quote
10MG 84 Get Quote
25MG 138 Get Quote
50MG 206 Get Quote
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Biological Information

  • Product Name
    NSC-66811
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.
  • Description
    A potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.
  • In Vitro
    NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf due to the functional activation of p53. Western Blot Analysis Cell Line:HCT-116 (p53+/+ and p53-/-) cells.Concentration:0, 5, 10, 20 μM.Incubation Time:48 h.Result:Dose-dependently induced the accumulation of p53, MDM2, and p21cip1/waf proteins in the HCT-116 human colon cancer cell line with wild-type p53. Had no effect on the levels for p53, MDM2, and p21cip1/waf protein in the isogenic HCT-116 p53-/- cell line.
  • In Vivo
    ——
  • Synonyms
    NSC66811 | NSC 66811
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    6964-62-1
  • Formula Weight
    340.426
  • Molecular Formula
    C23H20N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (293.75 mM)
  • SMILES
    OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4
  • Chemical Name
    2-methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lu Y, et al. J Med Chem. 2006 Jun 29;49(13):3759-62.PMID: 16789731
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