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NSC-66811
CAS No. 6964-62-1
NSC-66811( NSC66811 | NSC 66811 )
Catalog No. M15667 CAS No. 6964-62-1
A potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 36 | Get Quote |
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| 5MG | 58 | Get Quote |
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| 10MG | 84 | Get Quote |
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| 25MG | 138 | Get Quote |
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| 50MG | 206 | Get Quote |
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| 100MG | 308 | Get Quote |
|
| 200MG | 447 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNSC-66811
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.
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DescriptionA potent, MDM2-p53 interaction inhibitor with Ki of 120 nM, activates p53 in cancer cells.
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In VitroNSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf due to the functional activation of p53. Western Blot Analysis Cell Line:HCT-116 (p53+/+ and p53-/-) cells.Concentration:0, 5, 10, 20 μM.Incubation Time:48 h.Result:Dose-dependently induced the accumulation of p53, MDM2, and p21cip1/waf proteins in the HCT-116 human colon cancer cell line with wild-type p53. Had no effect on the levels for p53, MDM2, and p21cip1/waf protein in the isogenic HCT-116 p53-/- cell line.
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In Vivo——
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SynonymsNSC66811 | NSC 66811
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number6964-62-1
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Formula Weight340.426
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Molecular FormulaC23H20N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (293.75 mM)
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SMILESOC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4
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Chemical Name2-methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu Y, et al. J Med Chem. 2006 Jun 29;49(13):3759-62.PMID: 16789731
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