Cart
sales@molnova.com
Home - Products - Apoptosis - MDM2-p53 - NSC-319726

NSC-319726

CAS No. 71555-25-4

NSC-319726( NSC319726 )

Catalog No. M15734 CAS No. 71555-25-4

NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 29 In Stock
5MG 47 In Stock
10MG 77 In Stock
25MG 143 In Stock
50MG 259 In Stock
100MG 441 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    NSC-319726
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator.
  • Description
    NSC-319726 (NSC319726) is an allele-specific p53 mutant reactivator; restores WT structure and function to the p53(R175) mutant; kills p53(R172H) knockin mice with extensive apoptosis and inhibits xenograft tumor growth in a 175-allele-specific mutant p53-dependent manner.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC319726
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    p53(R175)
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    71555-25-4
  • Formula Weight
    234.3207
  • Molecular Formula
    C11H14N4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 27.5 mg/mL
  • SMILES
    C/C(=N\NC(=S)N1CCC1)/C2=CC=CC=N2
  • Chemical Name
    1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yu X, et al. Cancer Cell. 2012 May 15;21(5):614-25. 2. Yu X, et al. Oncotarget. 2014 Oct 15;5(19):8879-92. 3. Yu X, et al. Mol Pharmacol. 2017 Jun;91(6):567-575. 4.?Shimada K, et al. Cell Chem Biol. 2018 May 17;25(5):585-594.e7.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AM-7209

    A potent and selective inhibitor of the MDM2-p53 interaction with Kd of 38 pM, and IC50 of 1.6 nM.

  • Idasanutlin

    Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM.

  • Nutlin-3

    Nutlin-3 is MDM2 antagonist. Nutlin-3 inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53.

Sign In Join Free